Mount Sinai St. Luke’s and Mount Sinai West
|Center, Institute, Program||University Medical Practice Associates
|Medical Specialty||Pulmonary Medicine
Critical Care Medicine
COPD (Chronic Obstructive Pulmonary Disease)
Alpha 1 antitrypsin deficiency
Interstitial lung disease
|Insurance|| See Insurance Providers
|Board Certifications||American Board of Internal Medicine, 1981
American Board of Internal Medicine, Pulmonary Disease, 1983
American Board of Internal Medicine, Critical Care Medicine, 1987, recertified, 1997
|Medical School||London University, St. Mary's Hospital Medical School, London, England, 1975
|Residency Training||Internal Medicine, SUNY Health Science Center at Stony Brook, NY, 1978‑1980
|Fellowship||Pulmonary Medicine, Mount Sinai Hospital, New York, NY, 1980‑1982
|Academic Appointment||Icahn School of Medicine at Mount Sinai
|Research / Advances||Dr. Edward Eden's research interests include investigation of lung-related illnesses, disorders and treatments. He has served as the principal investigator for various projects, including
The Alpha-1 Foundation study targeted on the detection of alpha-1 antitrypsin deficiency in patients with COPD, and the COPD Foundation bronchiectasis registry consortium. He was co-investigator for research of HIV infection in alveolar macrophages, and co-investigator for a study of the national registry of patients with alpha-1 antitrypsin deficiency-related emphysema.
Eden E and Turino GM. Recombinant gamma-interferon augments interleukin-1 from endotoxin-stimulated human alveolar macrophages. Am Rev Resp Dis. 1986;133:455-460.
Eden E and Turino GM: Interleukin-1 secretion from alveolar macrophages of patients with AIDS, sarcoidosis and fibrosis. J Clin Immunol. 1986;6:326-333.
Eden E and Turino GM: Therapeutic applications to the pulmonary circulation in chronic obstructive pulmonary disease. Seminars in Resp Med. 1986;8:184-194.
Potash MJ, Zeia M, Huang ZB, Pearce TE, Eden E, Gendelman HE and Volsky DJ: Virus-cell membrane fusion does not predict efficient infection of alveolar macrophages by human HIV-1. Virology. 1992;188:864-68.
Huang ZB, Potash MJ, Simon M, Shahabuddin M, Chao W, Gendelman HE, Eden E and Volsky DJ: Infection of alveolar macrophages with lymphotropic HIV-1 can be arrested after viral DNA synthesis. J Virol. 1993;67:6893-96.
Barker A, Brantly M, Cohen A, Connelly R, Crystal R, Eden E, Stoller JK, Turino GM. Clinical features of Individuals with the PiSZ phenotype of alpha 1-antitrypsin deficiency. Am J Respir Crit Care Med. 1996;154:1718-1725.
Eden E, Mitchell D, Mehlman B, Khouli H, Nejat M, Grieco MH and Turino GM: Atopy, asthma and emphysema in patients with severe alpha 1-antitrypsin deficiency. Amer J Respir Crit Care Med. 1997;156:68-74.
Survival and FEV1 decline in individuals with severe deficiency of alpha-1 antitrypsin. The alpha-1 antitrypsin deficiency Registry study group. Am J Respir Crit Care Med. 1998;158 49-59.
Eden E: The Relationship between alpha-1 antitrypsin deficiency and asthma. Respiratory Care. March 3 1998, http://www.medscape.com.
Eden E, Hammel J, Rouhani F, Brantly ML, Barker AF et al. Asthma Features in Severe alpha 1-antitrypsin Deficiency. Experience of the NHLBI Registry. Chest. 2003;123: 765-771.
Member Lung disease Writing Group ATS/ACCP/ERS Joint Statement: Standards for the Diagnosis and Management of Individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168:820-896.
Eden E, Strange C, Holladay B, Xie L. Asthma and allergy in alpha-1 antitrypsin deficiency. Respiratory Medicine. 2006;100: 1384-1391.
Eden E, Holbrook JT, Brantly ML, Turino GM, Wise RA. Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma—Results from the ALA-ACRC Low dose Theophylline trial. J Asthma. 2007;44:605-608.
Demeo DL, Sandhaus RA, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard S, Burchard E, Stocks JM, Stoller JK, Strange C, Turino GM, Campbell EJ, Silverman EK. Determinants of airflow obstruction in severe alpha 1-antitrypsin deficiency. Thorax. 2007;62: 806-813.
DeMeo D, Campbell EJ, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard SI, Sandhaus SA, Stocks JM, Stoller JK, Strange C, Turino GM, Silverman EK. IL10 polymorphisms are associated with airflow obstruction in severe alpha 1-antitrypsin deficiency. AJRCMB. 2008,38(1):114-2.
ElSayegh D, Eden E, Shapiro J. Increasing Severity of Status Asthmaticus in an Urban Medical Intensive Care Unit. J Hospital Medicine. 2008;3:206-11.
Eden E and Turino GM. á1-Antitrypsin Deficiency. Lessons from Longevity. Editorial Chest. 2009;135:591-592.
Castaldi PJ, DeMeo DL, Kent DM, Campbell EJ, Barker A.F., Brantly ML., Eden E, McElvaney N.G., Rennard S.I., Stocks J. M., Stoller J.K., Strange C., Turino G., Sandhaus R.A., Griffith J.L., Silverman E.K. Development of Predictive Models for Airflow Obstruction in Alpha-1 Antitrypsin Deficiency, American Journal of Epidemiology. 2009;170(8):1005-13.
Eden E. Diagnosis and Treatment of severe Alpha-1 Antitrypsin deficiency. U.S. Respiratory Disease. 2010;5:24-27.
Eden E. Asthma and COPD in Alpha-1 Antitrypsin Deficiency. Evidence for the Dutch Hypothesis. COPD. 2010;5:366-374.
Rahaghi F; Sandhaus R; Strange C, Hogarth K, Eden, E, Stocks, J, Krowka, M,
Stoller J. The prevalence of alpha-1 antitrypsin deficiency among patients found
to have airflow obstruction. Journal of COPD. April 2012.
Kim WJ, Wood AM, Barker AF, Brantly ML, Campbell EJ, Eden E, McElvaney G, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Silverman EK, Stockley RA, DeMeo DL. Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respiratory Research 2012, 13:16 doi:10.1186/1465-9921-13-16.
Grosu, HB, Killam J, Khusainova E, Lozada J ,Needelman A, Eden E. Gene, host and environmental interactions in a 19 year old with severe chronic obstructive lung disease; observations regarding the pathophysiology of airflow obstruction. Interntional Journal of COPD. 2012;7: 383-388.
Grosu HB, Lee YI, Lee J, Eden E, Eikermann M, Rose KM. Diaphragm muscle thinning in patients who are mechanically ventilated. Chest. 2012;142:1455-1460.
Wexelman BA, Eden E, Rose KM. Survey of New York City resident physicians on cause-of-death reporting, 2010. Prev Chronic Dis. 2013;10:120288.
Shujaat, A, Shapiro JM, Eden E. Utilization of CT pulmonary angiography in suspected pulmonary embolism in a major urban emergency department. Pulmonary Medicine.
2013;2013:915213. doi: 10.1155/2013/915213.
|From the doctor||Dr. Edward Eden joined St. Luke’s and Roosevelt Hospitals (SLR) in 1985. In 2003, he was appointed SLR’s Chief of Pulmonary, Critical Care and Sleep Medicine, a position he now holds within the Mount Sinai Health System. Dr. Eden is the Director of the James P. Mara Center for Lung Disease, a ‘Center of Excellence’ for alpha-1 antitrypsin deficiency and other lung disorders. He is also Director of the Pulmonary Rehabilitation Program and Pulmonary Function Laboratories.
Dr. Eden has a strong interest in teaching. He is the director of the Pulmonary, Critical Care and Sleep Medicine fellowship training program and is active in medical student education.
Dr. Eden has served as an expert witness and a claims advisor in local and national cases concerning pulmonary and critical care medicine. He is an impartial specialist in the area of pulmonary medicine for New York State Workman’s Compensation Board. Dr. Eden has also served as a reviewer for the Office of Professional Medical Conduct NYS.
NY Times Magazine
2005, 2000, 1999
Best Doctors in NY
New York Magazine
Alpha-1 Foundation Designated Alpha-1 Expert
Clinical Resource Center, Mount Sinai-Roosevelt Hospital
|Address||425 W 59th Street, Suite 8A
New York NY 10019
Telephone: (212) 523-8672
Fax: (212) 492-5505